Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation.
نویسندگان
چکیده
Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificity of protein farnesyltransferase from S. cerevisiae.
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عنوان ژورنال:
- Chemical communications
دوره 48 66 شماره
صفحات -
تاریخ انتشار 2012